الفهرس 
REEVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
MSG is a well-known flavor enhancer used in both western and eastern cuisines. It is the sodium salt of glutamic acid which is one of the most common amino acids produced in the body. The Vitamin C is an essential micronutrient required for normal metabolic functioning of body. This study aimed to throw more light upon the histological effect of MSG on the renal cortex of adult male albino rats. Materials and Methods: The animals were classified into three equal groups (15 animals each): Control: Animals were received ordinary food, treated: Animals were received the dose of MSG in the form of 6 g thoroughly mixed with foods for two weeks and vitamin C supplemented: Animals were received the dose of MSG as previously mentioned daily for two weeks then MSG administration was stopped and the rats were received 250mg/kg of vitamin C daily for one week via orogastric tube. At the end of the experiment, blood samples were collected from orbital veins for serum creatinine and blood urea nitrogen. The kidneys were carefully dissected out and processed for light microscope study using hematoxylin and eosin stain, periodic acid Schiff (PAS) and immunohistochemical technique: For detection of apoptosis using Caspase 3, transmission electron microscope, morphometric studies and statistical analysis. Results: Regarding the treated group, light microscope examination revealed small renal corpuscles with degenerated glomeruli and widened Bowman’s spaces. The renal tubules were degenerated with widened tubular lumena containing exfoliated cells. Electron microscope examination showed the glomerular basement membrane appeared thickened than in the control group. The lining epithelial cells of the proximal convoluted tubules were resting on a thickened basement membrane with shrunken heterochromatic nuclei, swollen mitochondria and small vacuoles. Tightly packed microvilli were appeared in some areas or completely absent from them in other ones and distal convoluted tubules were resting on a thickened basement membrane. They had oval shrunken heterochromatic nuclei and mitochondria. Regarding the vitamin C supplemented group, there was an improvement in the renal cortex structure except exfoliated cells were seen in some tubular lumena and shedding of cellular fragments. In conclusion, administrations of MSG induced toxic effects on the kidneys especially on the renal cortex. These toxic effects manifested by serologically, an elevation in the serum creatinine and BUN and histologically, there was a degenerative change in the cortical glomeruli and tubules. On the other hand, vitamin C can improve that toxic manifestation occurred by MSG through its antioxidant effects. In view of the correlation between the adverse histological and serological effects and the administration MSG it is recommended that, use of an alternative safe food additive or restrict the addition of MSG to the food. Moreover, as the vitamin C is essential material used as antioxidant agents so it is recommended diet rich in vitamin C.