الفهرس 
DIABETIC POLYNEUROPATHYOnly 14 pages are availabe for public view
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Abstract
In this research our aim is to elucidate the subjective and objective efficacy of ozone &TENS therapies on NCS in type2 diabetic patients with peripheral neuropathy.
The present study was performed on 15 patients diagnosed as having type 2 diabetes mellitus with diabetic peripheral neuropathy from Diabetes and Endocrinology Out-Patient Clinic of Ain Shams University Hospital and Al Haram Hospital (Ministry of Health and Population).
This study was done during the period from Octoper 2007 to Octoper 2008.
All the patients in the study were subjected to full history, clinical examination, and assessment of fasting and 2hrPP blood sugar, Hba1c, serum urea, creatinine, urine analysis, albumin/creatinine ratio, and fundus examination. All these investigations were done before starting the sessions of ozone & TENS therapies.
Nerve conduction study was done to the patients before and after ozone therapy to detect if there is any improvement in the parameters of the nerve conduction study that may be parallel to the clinical improvement.
In the present study, 11 out of 14 patients showed improvement in the NCS as regard nerve conduction velocity. This improvement may be due to a successful remyelination process along the peripheral nerves that is mostly due to ozone effect as powerful antioxidants against oxidative stress and reactive oxygen species that developed from chronic hyperglycemia and caused the neuropathy.
In the present study, only 2 out of 10 patients with decreased amplitude in the NCS showed improvement. This decreased amplitude was found to be due to axonal degeneration so patients with decreased amplitude were found to have axonal degeneration which is a permanent problem and so there is no improvement in the amplitude.
Ozone had no effect on patients with delayed distal latency in the NCS as only one out of 6 patients showed improvement.
The effect of ozone therapy on NCS in type 2 diabetic patients with peripheral neuropathy was not influenced by many factors that were taken into consideration as follows: Age and sex, the level of fasting and 2hrPP blood glucose and kidney functions test. The correlation between Hba1c and ozone therapy also shows a non significant effect on the final results. Patients with normal fundus showed better response to ozone therapy compared to patients with NPD or PDR.
In addition to the improvement demonstrated by NCS also assessment of the degree of peripheral neuropathy in every one of the improved patient before and after ozone therapy by the United Kingdom screening test showed improvement in 9 out of 15 studied patients