الفهرس 
Rotavirus characteristics
Viral Proteins of RotavirusOnly 14 pages are availabe for public view
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Abstract
Rotavirus was first described in 1973. Rotavirus is the most important cause of acute diarrhea in young children and animals. Rotaviruses are non enveloped icosahedral virus and belong to the family Reoviridae.The viral capsid is triple-layered; the inner layer (VP1-VP3) contains the virus genome, which comprises 11 segments of double-stranded RNA, which encode six structural (VP1-VP4, VP6 and VP7) and six nonstructural (NSP1-NSP6) proteins. Each rotavirus gene segment codes for a single viral protein, except gene segment 11, which codes for two proteins, (NSP5 and NSP6). The middle capsid layer consists of VP6 which constitutes approximately 51% of the virus by weight. The high degree of identity (>87-99%) in the primary amino acid sequences of VP6 proteins from mammalian rotaviruses suggests that vaccines developed from VP6 of a group A human rotavirus strain may protect humans against all strains of group A rotavirus. The outer capsid layer consists of VP4, VP7 which are responsible for induction of neutralizing antibodies against rotavirus infection. The segmented genome of rotavirus is responsible for reassortment during co-infection and virus evolutionRotavirus is transmitted primarily by the fecal-oral route, through contaminated water or food. Rotaviruses infect the mature enterocyte of the small intestine.