الفهرس 
introductionOnly 14 pages are availabe for public view
 |  | from | 81 |  |  |
| | | from | 81 | | |
Abstract
Hepatic Failure is simply defined as a failure of the liver to
perform its function.It can complicate almost all forms of liver disease
and this will result in disturbances of different body systems especially,
severe neurological manifestations due to advanced Hepa tic failure e.g.:
in cirrhotic patients and usually among Egyptins of chronic bilharziasis.
Although the clinical features of Hepatic Failure may differ
depending upon the severity and duration of the disease, they are minimal
with no encephalopathy. One of the important features is -Iaundice owing
to failur of the liver cells to deal with bilirubin resulting in
Hyperbilirubinaernia, but, the overall picture and lines of treatment are
similar irrespective of the aetiology.
Hyperbihrubinaernia in infants and children has been reported to
cause sensorineural hearing loss but no such studies has been reported
about the effect of Hyperbilirubinaemia in adults with Hepatic Failure on
hearing.
So, this study tries to show the hearing profil in patients with
hepatic failure aiming to:
Determine the effect of Hepatic Failure on Hearing.
Correlate between duration of Hepatic Failure and Hearing loss.
Correlate between Hyperbilirubinaernia and Hearing loss.
Determine the effect of drugs used during history and managment
of Hepatic Failure on Hearing.
Afourty patients with Hepatic ”Failure that reffered to the Audiology
Unit in ENT. Department by Internal Medicine Department of Zagazig
University Hospitals, were used as study group and other twenty normal
subjects were chosen randomly from relatives of pa.Lients and the
Audiology U ni t personell as a control group.
The subjects of ages, in both groups, ranged between 22-65 years
and each one of them was subjected to the following: full investigations
including; History, Medical exam, Otological exam, Audiological
evaluation using Pure Tone Audiometer.rjbne decay and Tympanometry
and Laboratory investigations for the study group only especially total
serum bilirubin level.
It is, there-fore, recommended that:
- Patients with Hepatic Failure must be assessed audiologically,
- Auditory Brain-stern Response, ABR, is needed for audiological
assessment of patients with Hepatic Failure.
- Drugs used in treatment of Hepatic Failure might be given orally in
presence of vitamine A and B-complex with caution and close
audiological follow up.
- Further, Histopathological studies about the effect of bilirubin on the
cochlea by means of electronmicroscopy are needed.