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العنوان
ROLE OF CD15 IN THE DIAGNOSIS OF LUNG CANCER :
المؤلف
Fayed, Sherif Mohamed Fekry Moustafa
هيئة الاعداد
باحث / Sherif Mohamed Fekry Moustafa Fayed
مشرف / Osama Fahim Mansour
مشرف / Ahmed Abdel-Rahman Aly
مشرف / Nourane Yehia Azab
الموضوع
Small cell lung cancer. Evidence-based medicine.
تاريخ النشر
2005.
عدد الصفحات
1comouter optical disc ;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب
تاريخ الإجازة
1/1/2004
مكان الإجازة
جامعة المنوفية - كلية العلوم - chest diseases
الفهرس
Only 14 pages are availabe for public view

from 120

from 120

Abstract

Lung cancer is the leading cause of cancer deaths in developed countries. The poor prognosis associated with this disease is closely related to the fact that most lung cancer patients are not identified until their malignancy has reached an advanced stage. Around 80% of patients with lung cancer have stage III or IV disease at presentation, which excludes them from potentially curative surgical resection. Detection of the tumor at an earlier stage leads to an improved prognosis. Patients presenting with stage Ia non-small cell lung cancer and undergoing surgical resection have a 5 year survival of around 60%. (2)
Recent advances have added to the understanding of the morphological and molecular characteristics of pre-invasive bronchial lesions and early lung cancers. Such information is being used to provide new tests for the detection of lung cancer at early or pre-invasive stages, and for identifying targets for therapeutic intervention that can prevent progression to advanced disease.
CD15 (Leu M1, Lewis x or Stage Specific Embryonic Antigen-1 (SSEA-1)) is an embryonic carbohydrate antigen. The majorities of cancer associated carbohydrate antigens are differentiation antigens and are specifically expressed in immature cells. The retro-differentiation nature of cancer cells in the course of malignant transformation to simulate embryonic lung cells explains why they express the immature cell-specific carbohydrate antigens such as SSEA-1.