Search In this Thesis
   Search In this Thesis  
العنوان
Biochemical Studies on Some Radiopharmaceuticals
المؤلف
Bekheet Mohamed Bekheet ,Safaa
هيئة الاعداد
باحث / Safaa Bekheet Mohamed Bekheet
مشرف / Ibrahim Hassan Borai
مشرف / El-Sayed Abd El-Ghany
الموضوع
Single Photon Emission Computed Tomography .
تاريخ النشر
2010.
عدد الصفحات
154.P؛
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Biotechnology
تاريخ الإجازة
1/1/2010
مكان الإجازة
جامعة عين شمس - كلية العلوم - Biochemistry
الفهرس
Only 14 pages are availabe for public view

from 144

from 144

Abstract

A radiopharmaceutical may be defined as a chemical or pharmaceutical preparation labeled with a radionuclide in tracer or therapeutic concentration, used as a diagnostic or therapeutic purposes of human diseases. A radiopharmaceutical agent is usually administrated into a vein. Depending on which type of scan is being performed, the imaging will be done either immediately, a few hours later, or even several days after injection. Imaging time varies, generally ranging from 20 to 45 minutes.
The active ingredient, that is the actual radiolabeled chemical, is usually present in minute amount, typically less than a nanogram and far below the amount necessary to initiate any physiological response in an individual.
The characteristics of an ideal radioisotope for therapy are quite different from those required for imaging. For imaging, the radioisotopes energy must be suitable for the camera crystal, without significant absorption by the tissue. whereas, the energy of a therapeutic radioisotope must be deposited in the tissue to damage the DNA chains to keep the diseased cells from replicating.
-95- Summary
The radiopharmaceutical that is used is determined by what part of the body is under study, since some compounds collect in specific organs better than others.
Deals with the different methods of labeling with Technetium-99m and radioactive Iodine using an electrophilic substitution reaction by using Chloramine-T or Iodogen as an oxidizing agents, also the different methods which used for separation, purification of labeled compound.
Since the radiopharmaceuticals compound are usually administrated to humans, so its must be subjected to all quality control tests such as radiochemical purity to ensure necessary purity, safety and efficiency of these products for the intended nuclear medicine applications
.