الفهرس 
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Abstract
Several previous studies suggested that microalbuminuria, the early
phase of diabetic nephropathy is associated with increased risk of
cardiovascular morbidity and mortality, but the mechanism of this association is not clear.
The aim of this work was to study prothrombin F 1 +2 in IDDM with
and without microalbinuria.
This work was conducted on 30 cases of IDD patient classified as
follow: 15 IDD patient with microalbuminuria and 15 IDD patient without
microalbuminuria and 10 apparently healthy subjectes surved as a control
group.
All the subjects were examined and investigated as follows:
1- Complete urine analysis.
2- Fasting and post prandial blood sugar.
3- Serum Urea and creatinine.
4- Assay of A.E.R.by microalb. immunoturbidimetric method.
5- Assay of prothrombin F 1 +2 by ELISA using enzygions F 1 +2 micro.
6- Routine coagulation study: PT, PTT, TCT and Platelets count.
Our results found that Fl +2 show higher levels in cases of IDDM
with microalb. than IDDM without microalb. Positive correlation between
Fl+2 and A.E.R. was observed in group 1 (Microalb.), as well as group 2
(norrnoalb.). Also positive correlation between Fl +2, age, duration of
disease and blood glocuse (fasting and post brandial).