الفهرس 
I. INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid progenitor cells, affects both children and adults, with peak prevalence between the ages 2-5 years. Chemotherapy is the initial treatment of choice for ALL. In general, cytotoxic chemotherapy for ALL combines multiple antileukemic drugs in various combinations. Chemotherapy induced peripheral neurotoxicity is an important side-effect of several chemotherapeutic agents.
Twenty four patients newly diagnosed as ALL were enrolled into the present study; they were subjected to clinical and electrophysiological assessments which assess the integrity of the peripheral nervous system through conducting nerve conduction study and electromyography before and after receiving the chemotherapeutic agents. The 24 patients constituted groups I and another 10 free children (do not have ALL and did not receive chemotherapy) were taken as a control group, which constituted group II.
The electrophysiological assessment included nerve conduction study to the following nerves: Ulnar nerve (sensory & motor), Median nerve (sensory & motor), Sural nerve, Common peroneal nerve and posterior tibial nerve. Also the F-response and H-reflex were included as well as a needle electromyography for the following muscles: Deltoid, 1st dorsal interosseous, vastus medialis and tibialis anterior muscle.