الفهرس 
Breast CancerOnly 14 pages are availabe for public view
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Abstract
Summary
Breast cancer is the most frequently diagnosed cancer
worldwide. It is the commenst cause of death in women.
Several studies suggested that some types of viruses
especially Human Papilloma virus might be involved in the
pathogenesis of breast cancer.
Viruses developed numerous ways to evade the host
immune system. For example, HPV is able to block Fas
mediated apoptosis. Several studies found that cancer cells
positive for HPV are resistant to apoptosis.
Fas/FasL is the major regulator of apoptosis which is
involved in cancer cell death by the immune system. In spite
of that it was found that breast cancer cells are resistant to
apoptosis.
The aim of this study was to detect the presence of
HPV type 16 in breast carcinoma by targeting the E6 region
and to assess Fas and FasL expression along with evaluating
their correlation with clinicopathological parameters in breast
carcinoma.
This retrospective study comprised 45 formalin fixed
paraffin-embedded tissue specimens of breast lesions. They
were divided into two groups:
Group I (malignant breast lesions): It included thirty
cases of invasive breast carcinoma.
Group II (benign breast lesions): It included fifteen
cases with benign breast lesions.
We found a significant down-regulation of Fas expression
and up-regulation of FasL expression in invasive breast
carcinomas versus benign breast.
Summary and Conclusions
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-There was no significant relation between age of patients
and Fas, FasL and HPV-16.
- There was a significant inverse relation between tumor
size and Fas and no significant relation with both FasL
and HPV-16.
- There was a significant direct relation between ER status
and Fas and a significant inverse relation with both FasL
and HPV-16.
- There was a significant inverse relation between PR
status and HPV-16 and no significant relation with both
Fas and FasL.
-There was a significant inverse relation between tumor
stage and Fas and a significant direct relation with both
FasL and HPV-16.
-There was a significant inverse relation between L.N
status and Fas and a significant direct relation with both
FasL and HPV-16.
-There was a significant inverse relation between tumor
grade and Fas and a significant direct relation with FasL
and no significant relation with HPV-16.
-There was a significant direct relation between Her/2 neu
and HPV-16 and non significant relation with both Fas
and FasL.
-There was a significant inverse linear correlation
between Fas and FasL expression as well as a significant
inverse linear correlation between Fas expression and
HPV-16 in breast carcinoma.