الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Part I
This part presents an introduction about the chemical name, structures, physical properties and pharmacological action of studied drugs. It also contains literature review for the reported methods of analysis of the selected drugs in pharmaceutical dosage forms as well as in biological fluids.
Part II
This part discusses the application of chemometrics to the handling of HPLC response data using the internal standard method (ISM). This was performed on a model mixture containing terbutaline sulphate, guaiphenesin, bromhexine HCI, sodium benzoate and propylparaben as internal standard. Derivative treatment of chromatographic response data of analyte and internal standard was followed by convolution of the resulting derivative curves using 8-points sin xi polynomials (discrete Fourier functions). The response of each analyte signal, its corresponding derivative and convoluted derivative data were divided by that of the internal standard to obtain the corresponding ratio data. This was found beneficial in eliminating different types of interferences. It was successfully applied to handle some of the most common chromatographic problems and non-ideal conditions, namely: overlapping chromatographic peaks and very low analyte concentrations. For example, a significant change in the correlation coefficient of sodium benzoate, in case of overlapping peaks, went from 0.9987 to 0.9994 on applying normal conventional peak area and first derivative under Fourier functions methods, respectively.