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العنوان
Contribution to The Analysis Of Some Drugs Used In the Treatment Of Cardiovascular Disorders /
المؤلف
El-Kimary, Eman Ibrahim Saleh.
هيئة الاعداد
باحث / Eman Ibrahim saleh El-Kimary
مشرف / Magda Ahmed Hamdy Barary
مشرف / Ekram Mahmoud Hassan Abdallah
مشرف / Hadir mohamed Maher Ibrahim
مشرف / Rasha Moustafa Mohammed Youssif
الموضوع
Pharmaceutical Analytical Chemistry.
تاريخ النشر
2011 .
عدد الصفحات
191 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الصيدلية
تاريخ الإجازة
1/1/2011
مكان الإجازة
جامعة الاسكندريه - كلية الصيدلة - pharmaceutical Analytical Chemistry
الفهرس
Only 14 pages are availabe for public view

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from 223

Abstract

This part contains a general introduction about the chemical names, structures, physical properties, pharmacological actions and uses of the studied drugs. It also contains literature reviews for the reported methods of analysis for the selected drugs in pharmaceutical dosage forms as well as in biological fluids.
Part II
This part deals with the analysis of ternary mixture of amiloride hydrochloride, atenolol and chlorthalidone using spectrophotometric and chromatographic methods of analysis. This part comprises two chapters.
Chapter one:
In this chapter, three spectrophotometric methods were applied for the simultaneous determination of amiloride hydrochloride, atenolol and chiorthalidone without prior separation steps. The first method is derivative ratio spectra-zero-crossing method. By using amiloride hydrochloride as a divisor, atenolol and chlorthalidone can be determined by measuring the first derivative signals of the ratio spectra at 240 (corresponding to chiorthalidone zero-crossing) and 234 nm (corresponding to atenolol zero-crossing), respectively, while amiloride hydrochloride was measured at 293 nm which corresponds to chiorthalidone zero-crossing after using atenolol as a divisor.