الفهرس Only 14 pages are availabe for public view
 |  | from | 229 |  |  |
| | | from | 229 | | |
Abstract
The two main factors to be considered in the manufacture of film-based TDDS are the mechanical and adhesive properties of the casted films. These properties affect the fabrication process as well as clinical application usefulness of the TDDS. So optimising these properties is a key factor for a successful manufacture of TDDS.
The objective of this part was to study the effect of three different plasticizers; namely dibutyl phthalate (DBP), diethyl phthalate (DEP) and triacetin; on the mechanical properties, adhesiveness and tack of casted Eudragit E-100 films. Also influence of the incorporation of different cross-linkers in varying concentrations in the casted films on their mechanical properties was to be investigated. Finally, moisture uptake and occlusiveness (water vapour transmission) of the films were to be studied due to their potential effect on skin hydration and hence transdermal drug delivery.