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Abstract The present study investigates the zoonotic potential of Helicobacter pylori as well as scoping on the epidemiology of thermophilic Campylobacter species. For this purpose fecal, milk, abomasal and blood samples were collected from cattle and sheep. Also, fecal, saliva and blood samples were collected from human contacts. The results revealed that Campylobacter jejuni was important cause of enteritis in cattle, sheep and human especially in youngs. Moreover, it played an important role in sub clinical mastitis in dairy cattle. On the other hand, sheep were considered as an important reservoir for H. pylori rendering persons in regular contact with sheep at great risk for contracting the infection and thus, H. pylori should be considered as zoonosis. |