الفهرس 
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Abstract
The pharmacokinetics of tulathromycin and its effect on abomasal
emptying rate were investigated in lactating goats. Five goats received 2.5
mg/kg of tulathromycin by either (i.m.) or (i.v.) route with six weeks
interval. Tulathromycin concentrations were determined in blood, milk and
urine samples by microbiological assay method. Tulathromycin effect on
abomasal emptying rate was estimated by paracetamol absorption test.
Paracetamol concentrations determined in blood samples by colorimetric
nitration assay. After IM injection, (Cmax) was reached at 0.5 h postinjection
(tmax) and F% of 95.8 ± 6.5 % was acheived. After IV injection the (Vss) was
16,075 ± 2,049 mllkg. The ratios between Cmax-milk/Cmax-plasma and AUC milk
fAUC plasma were high. Gastric emptying half life Tso after IM, IV was
shorter than in control experiment. In conclusion, tulathromycin is rapidly
absorbed with high bioavailability, highly distributed in tissues, slowly
eliminated and extensively penetrating into milk. Tulathromycin has
accelerating effect on abomasal emptying rate.