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Abstract
The goal of the present study was to investigate the effect of atorvastatin and Cinnamomum Zeylanicum on body weight, histopathological and various biochemical parameters of hypercholesterolemic rats.
Adult male albino rats (130-190 g) were allocated for the present study. After acclimatization period of two weeks, the animals were fed a hypercholesterolemic diet (1% cholesterol and 0.2% cholic acid). Fifteen days after feeding hypercholesterolemic diet, rats were screened for measuring blood total cholesterol. The mild hypercholesterolemic rats (rats having serum total cholesterol ranging from 70-120 mg/dl) were divided into three groups and each group in turn was subdivided into two subgroups based on time factor. The first group considered as hypercholesterolemic control for treatment groups. The other two groups were treated separately with atorvastatin (0.2 mg/kg b. wt.), and cinnamomum ( mg/kg b. wt.). All treatments were applied orally by gastric intubation and daily for 3 and 6 weeks.
Another group of normal animals was kept under the same laboratory conditions and regarded as control for the hypercholesterolemic ones.
After the 3rd and the 6th week of starting the treatments, livers were quickly removed after dissection of the sacrificed animals and were taken for studying the histopathological changes. Blood and liver samples were collected for the determination of (1) serum lipidograms (total lipids, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol and cardiovascular risk), (2) total proteins and its fraction, (3) serum (urea, uric acid and creatinine) concentration (4) the activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) (5) the activity of hepatic catalase (CAT), superoxide dismutase (SOD) and peroxidase (Px) and liver glutathione (GSH) contents (6) hepatic lipid peroxidation and (7) serum nitric oxide (NO) and homocysteine concentrations.