الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Tinnitus is known to occur as a concomitant of almost all the dysfunctions that involve the human auditory system. While tinnitus is typically a temporary sensation, it may develop into a chronic condition that is resistant to medical treatment. Several studies reported improvement of subjective tinnitus annoyance and intensity using gabapentin in combination with clonazipam. In the light of the promising clinical studies, this study was designed to evaluate the effectiveness of gabapentin (alone or with combination of clonazepam) in treatment of tinnitus patients.
A total number of 134 tinnitus patients were examined in this study. All patients were subjected to detailed history, vital signs examination, otologic examination, head and neck examination, basic audiological evaluation including pure tone audiometry, speech audiometry, tympanometry and acoustic reflex testing, and referral to other specialties if needed. At this stage of examination thirty four patients were excluded according to the study protocol (did not fit the inclusion criteria as they did not have subjective idiopathic tinnitus).
The study was continued for 100 patients with subjective idiopathic tinnitus. Three groups were randomly chosen, group for gabapentin therapy (study group A), group for combined gabapentin and clonazipam therapy (study group B) and group for placebo (placebo group). The following were done: tinnitus matching, loudness discomfort level (LDL), psychological scales (Rotter Incomplete Sentences Blank (RISB) Arabic version and Taylor Manifest Anxiety Scale (TMAS) Arabic version), tinnitus questionnaires (Tinnitus Handicap Inventory Questionnaire (THI) Arabic version and tinnitus cognition questionnaire (TCQ) Arabic version and mismatch negativity (MMN) test. The Tinnitus cognition questionnaire (TCQ) developed by (Wilson and Henry, 1998) was translated into Arabic language and used to assess subjective cognitive responses in relation to tinnitus.
Norms data of MMN test of 20 normal hearing subjects were used for statistical comparison with that obtained from tinnitus patients. There was no significant difference between normal and tinnitus subjects for MMN amplitude or latency at 1 KHz stimulus. On the other hand, highly statistical significant differences were seen for MMN test amplitude and latency at 4 KHz. Tinnitus patients had relatively longer latencies and lower amplitudes than normal subjects especially at higher f