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Abstract
Biochemical Alteration In Trace Elements
In Chronic Hepatitis C Infected Patients Hepatitis C is responsible for many chronic liver diseases and it is related with hazard changes in liver from simple histologic change to hepatic cirrhosis and liver cancer.The chronic liver diseases are considered as the most spreading diseases among Egyptians and which cause many death cases among liver patients therefore, there is a permanent search in diagnosis methods and treatment for these diseases.One of liver diseases which have enormous researches is the chronic hepatitis C. Therefore, this study aims to : 1- The relationship among some trace elements such as (iron, zinc, Copper, cobalt, Aluminum, Manganese) in serum of patient infected by liver disease and its relationship with the development of there diseases in various ages . 2- The relationship between some trace elements and severe of the liver disease throughout the various liver functions.3- Comparing these changes with the Hepatitis C patients accompanied with schistosomiasis as well as hepatitis C patients who suffer from chromic renal failure To make a procedure for this study, four groups have been adopted.Each one includes 30 persons.These groups were divided as follow The first group includes 30 healthy persons as control divided into : A1) Ten persons less then 30 years. A2) Ten persons form 30-50 years. A3) Ten persons more than 50 years.The second group includes 30 persons who suffer from hepatitis C patients divided into B 1) 10 hepatitis C patients less than 30 years.B2) 10 hepatitis C patients from 30 - 50 years.B3) 10 Hepatitis C patients more than 50 years The third group includes 30 persons who suffer from hepatitis C and schistosomiasis divided into : C1) 10 persons who suffer from hepatitis C and schistosomiasis less than 30 years . C2) 10 persons who suffer from hepatitis C and schistosomiasis from 30-50 years.C3) 10 persons who suffer from hepatitis C and schistosomiasis more than 50 years.The forth group includes 30 persons who suffer from hepatitis c and renal failure divided into : D1) 10 Hepatitis c and renal failure patients less than 30 years D2) 10 Hepatitis c and renal failure patients from 30-50 years. D3) 10 hepatitis c and renal failure patients more than 50 years. The disease career and clinical and laboratory check up have been put into consideration for these groups.Four blood samples have been already collected throughout 9 months, the first blood sample, then the second after 3 months, then the third one after 6 months, at last the fourth one after 9 months. According to the measurements of the level of zinc, copper, iron in serum of theses groups and the results were as follow : - There is significant decrease in 2zn result in all groups than control group and that is more decrees with increase of Age There is significant increase in Iron in HCV group and HCV with shistosoma group but there is significant decrease in iron serum in HCV with renal failure group.There is non significant decrease in cobalt in all groups.There is non significant decrease in copper in second and third groups but it is significant increase , in fourth group and increase with increase the age.There is non significant in crease in Mn in all groups There is significant decrease in Al in fourth group but non significant changes in other group.So chronic hepatitis C cases and schistosomiasis and also Hepatitis accompanied by chronic renal failure followed by shortage in trace elements levels, there fore it is recommended to follow it ration in blood and modify these levels if it is obligated.