الفهرس Only 14 pages are availabe for public view
 |  | from | 90 |  |  |
| | | from | 90 | | |
Abstract
Diabetes is associated with excess risk for coronary heart disease. Some of this excess risk relates to an increased prevalence of established risk factors. Nevertheless, these traditional risk factors do not fully explain the excess risk associated with diabetes. Therefore, other nontraditional risk factors may be important in people with diabetes.
Different traditional and nontraditional vascular risk factors, as inflammatory markers (IL1β and CRP), were assessed among the two case groups (diabetics with comorbidity and diabetics only) and a control group, each group comprises 30 patients, to find their relation to psychiatric disorders. Cases were subdivided to the two previously mentioned groups to assess if presence of comorbidity has a role in the development of psychiatric disorders.
As regard the inflammatory markers, the current study showed that diabetic groups had higher levels of IL1β and CRP. These results support the hypothesis that type II diabetes is associated with chronic low-grade inflammation.
The current study showed that psychiatric disorders, including depression, anxiety, cognitive impairment and delirium, were more among diabetics compared to controls with a highly significant difference and showed no statistically significant difference between the two case groups (diabetic only and diabetic with comorbidity) regarding psychiatric disorders.
Anxiety was found to be more among females with a high statistically difference compared to males while there was no statistically significant difference between males and females regarding depression, cognitive impairment and delirium.
It was found that depression, cognitive impairment and delirium were associated with higher levels of IL1β and CRP with a highly significant difference compared to those without psychiatric disorders while there was no statistically significant difference between cases with anxiety and those without psychiatric disorders regarding IL1β and CRP.
It was found that cases with cognitive impairment, depression and anxiety showed more use of insulin treatment in comparison to those free of psychiatric disorders showing more use of oral hypoglycemic drugs and these results were of a high statistically significant difference, while no statistically significant difference was found between delirious cases and those free of psychiatric disorders regarding treatment of diabetes.
The current study studied the relation between psychiatric disorders and vascular risk factors (including age, duration of DM, BMI, lipid profile and smoking).
The results showed no statistically significant difference between delirious cases and those free of studied psychiatric disorders regarding coronary risk factors while cases with cognitive impairment, anxiety and depression showed statistically higher BMI, longer duration of DM, higher levels of cholesterol, triglycerides, LDL and lower levels of HDL in comparison to those cases free of studied psychiatric disorders.
The results showed higher mean of age among cases with psychiatric disorders but it was of no statistically significant difference.
Regarding smoking the results showed lower number of smokers among cases with anxiety and higher number of smokers among cases with depression and cognitive impairment compared to those without psychiatric disorders. All these results were of no statistically significant difference.
The current study showed that the presence of high levels of inflammatory markers associated with diabetes can increase the risk of coronary heart disease among diabetics and that the presence of high prevalence of psychiatric disorders among diabetics has a significant relation to inflammatory markers and coronary risk factors associated with diabetes.