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Abstract
This work was done in hope to clarify the role of breast milk as a vehicle for
aflatoxin and ochratoxin in the infants and impact’of them in lactating infants.
50 exclusively healthy lactating mothers and their healthy exclusively lactating
infants, for at least 4 months, were included in this study. Full physical
examination was done for both infants and mothers. Samples of blood and breast
milk were collected from mothers and their infants and level of aflatoxin and
ochratoxin were detected. Serum creatinine, urea, uric acid, liver tests (ALT,
AST, serum albumin and prothrombine time) were determined. Infants’ urinary
microalbumin and B2-microglobulin levels were also determined.
The results of this study showed that:-
1- The mycotoxin detection rate was higher among mothers’ serum,
mothers’ milk and serum of their exclusive breast feed infants.
2- The contamination rate of ochratoxin was higher (72% for mothers’
serum and milk) than that for aflatoxin (48% and 50% for mothers
serum and mothers milk respectively) with higher positive
contamination rate in urban areas than in rural areas.
3- The levels (mean ± S.D ug/rnl) of aflatoxin and ochratoxin were
4.1715 ± 5.517 and 3.987 ± 4.0105 respectively in mothers’ serum,
0.957 ± 1.036 and 1.1505 ± 1.003 respectively in mothers milk and
0.858 ± 1.154 and 1.379 ± 1.92 in serums of their exculsive breast fed
infants, for aflatoxin and ochratoxin respectively.
4- There was no statistically significant difference between urban and
rural areas as regard to positive detection rate and levels of aflatoxin
and ochratoxin for mothers’ serum, mothers’ milk and infants’ serum.
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Summary,:. ’”’, . ’.._.’ .
5- Mothers milk aflatoxin showed a significant positive correlation with
infants serum aflatoxin (P=0.008) and with mothers’ serum aflatoxin I\.
(P=O,003),
6- A significant positive correlation was noted between mothers’ milk
ochratoxin and mothers serum ochratoxin (P < 0.001), while there was
no statistical significant correlation between mothers’ milk ochratoxin
and infants serum ochratoxin.
7- There was a significant negative correlation (P=0.023) between infants
serum aflatoxin and the residual of regression of length/age.
8- Both unne microalbumin and p2-microglobulin levels were
significantly higher in infants positive for ochratoxin or for ochratoxin
and aflatoxin than negative.
9- For infants’ serum positive for aflatoxin, there was no significant
alternation in their liver function findings.
10- No statistical significant differences in kidney function tests among
mothers positive for ochratoxin and/or aflatoxin versus negative ones.
11- There is statistically significant difference in prothrombin time in
mothers’serum positive for aflatoxin.