الفهرس | Only 14 pages are availabe for public view |
Abstract Apoptosis refers to energy-dependent cell death in which individual cells participate in their own fragmentation and deletion from living tissue. It is a natural and active process in normal and neoplastic tissues. The aim of this work was to study the role and regulation of apoptosis in different renal diseases that may improve our knowledge ofthe mode of action of current therapies, and it may also provide the basis for the design ofnew therapeutic strategies. This study was conducted on 80 children attending the pediatric Nephrology and dialysis unit of pediatric department, Zagazig University Hospital. They were divided into ”4” groups: Group (1): (20 cases) (a) Includes 10 cases (4 males and 6 females) suffering from chronic renal in sufficiency (CRI) and treated conservatively, their age ranged from (3-13) years with mean value of8.15±3.83 years. (b) Includes 10 cases (4 males and 6 females) suffering from end stage renal diseases (ESRD) and on regular hemodialysis their age ranges from (4-17 years) with mean value of 11.8±4.492 years in addition to conservative management, regular hemodialysis was conducted for 3-4 hr/session, 3 times a week, of single pass acetate hemodialysis, at a blood flow rate through double needle system of 125 mllmin and dialysate flow (Qo) of 500 rnl/min. During each session, high molecular weight heparin (50 Iu/Kg body weight) was administered to prevent coagulation. 154 - Hollow fiber poly sulfone dialyzer (fesenius medical care AG) were chosen according to the individual needs of the patients. - Measurement of serum lNFcx. and CD9S was done just before dialysis session and just after it. |