الفهرس Only 14 pages are availabe for public view
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Abstract
Methanol poisoning is a major problem and is responsible for innumerable deaths annually. in large parts of the developing world, especially among the economically depressed. Methanol is rapidly absorbed throughout the GIT and is converted in the liver into formaldehyde and then formic acid by the action of alcohol dehydrogenase and acetylaldehyde dehydrogenase. Methanol toxicity is mediated by its main metabolite, formic acid, which is responsible for metabolic acidosis, brain, and optical nerve lesions. Other organs, like the pancreas or the kidney, may also be damaged according to the severity of metabolic acidosis. Severe metabolic acidosis, coma and seizures at presentation are signs of poor prognosis. The kidney is not considered a target organ in methanol toxicity. In the current study we tried to determine the occurrence of renal injury in methanol toxicity and to clarify the factors associated with this injury. In this prospective study, 28 adult methanol intoxicated patients were selected. All patients were subjected to thorough.