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Abstract
Adrenomedullin (ADM), a ubiquitous regulatory peptide (52 amino acids) with different actions, is expressed in many tissues throughout the body including the adrenal medulla, endothelial and vascular smooth muscle cells.
This study was performed on 40 adult male white albino rats weighing 150-200 grams. The animals were subdivided into four equal groups control, ADM, L-Name and, ADM+L-NAME. All were expressed in the form of Mean ± SEM and statistical analysis detection of significance was performed by ANOVA.
As regard pancreatic function, in this study it was found that ADM administration induced a significant reduction in fasting serum insulin level without concomitant increase in blood glucose level which can be explained by the finding that ADM increased insulin sensitivity. Chronic blockade of NO pathway using L-NAME induced opposite effects to that of ADM in the form of a significant increase in insulin level, decreased blood glucose level and decreased insulin sensitivity. These effects of ADM on insulin and glucose were abolished by co-administration of ADM and L-NAME.
As regard lipid profile, in this study it was found that ADM administration induced a significant reduction of serum triglycerides, a significant increase of serum total cholesterol and LDL-cholesterol and has no effect on HDL-cholesterol in comparison with control group. Moreover, it was found that blockade of NO Pathway by L-NAME has no significant effect on total serum cholesterol, triglycerides, and HDL-cholesterol in comparison with control group, while it produced an insignificant change, however L-NAME induced a significant increase LDL-cholesterol was in comparison with control group (P<0.001). Meanwhile, the effect of combined administration both ADM and L-NAME has no significant effect on total serum cholesterol, triglycerides, and HDL-cholesterol in comparison with control group, while it produced an insignificant change, however L-NAME induced a significant increase LDL-cholesterol was in comparison with control group (P0.001). In conclusion, this study ADM has a beneficial effect on insulin sensitivity, and these effects can be reversed by L-NAME. However, ADM administration has a deleterious effects on lipolysis whether, ADM plays a protective or a worsening effect needs further investigations.