الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
SUMMERY AND CONCLUSION
This study included one of the most common dermatological disease which is pityriasis rosea. It represents about 2% of the dermatological patients who attend dermatological clinics. Pityriasis rosea is a common acute self limiting papulosquamous skin disease, affecting any age especially children and young adults between 15-35years. It is characterized by a distinctive skin eruption and minimal constitutional symptoms, such as fever, headache, and gastrointestinal discomfort.
The exact etiology of pityriasis rosea still remain unclear, and no pathologic microorganism has so far been isolated, and also there has been no definite evidence that implicates definite immunologic processes
Skin inflammation often depends on the action of T cells, IL-12 is an important cytokine produced by a variety of immune effector cells that leads to a type 1 helper T cells (TH1) response. IL-12 also directs T cells to the skin via induction of cutaneous lymphocyte antigen (CLA) expression.
Cytokines are amall to medium sized proteins and glycoproteins that mediate highly potent biological effects on many cell types. They are regulatory glycoproteins that can affect virtually every cell type in the body and have regulatory effects on many cell types such as nervous and immune systems.
Interleukin 12 (IL-12) is a heterodimeric cytokine produced by phagocytic cells, APCs such as dendritic cells and skin langerhans cells and B cells. IL-12 is composed of two covalently linked chains, the P40 (heavy chain) and P35 (light chain).
This study Included fifty patients:
• Twenty five patients with pityriasis rosea
• Twenty five healthy controls
The patients and controls were randomly collected from dermatology out patient clinic at Cuez Canal University and Ismailia general hospitals. An enzyme linked immuno sorbent assay (ELISA) performed on microtiter plate. The assay is based on an oligoclonal system in which a blend on momoclonal antibodies (MAbs) directed against distinct epitopes of IL-12 are used, in order to investigate the possibility that IL-12 could be involved in the pathogenesis of pityriasis rosea.
The results of this study showed that the level of IL-12 ranged from 30-320 pg/ml in patients while in controls the level of IL-12 ranged from 28-60pg/ml, the comparison showed that the level of IL-12 in serum was significantly increased in patients than healthy controls. As regard the symptomatic PR, the IL-12 level was significantly increased in itchy PR more than asymptomatic PR as well as PR with mild itching. The level of IL-12 is also significantly increase in inflammatory (irritated) PR more than non inflammatory (non irritated) PR, and significantly increased in cases with face affection.
In conclusion, this study showed that IL-12 may play a role in pathogenesis and clinical symptoms of PR as it was found that the difference in the level of IL-12 in both PR patients and controls was highly statistically significant (p≤0.01).
For our results to be confirmed, assessment of IL-12 serum level after recovery of patients is mandatory, and further studies are necessary to investigate the involvement of IL-12 in PR in order to answer the question whether this cytokine play a role in the pathogenesis and clinical course of PR.