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Abstract
Preservatives consider one of the most important food additive that used in most
food industry like meat, fish, oil and others. The aim of this study is to determine
the effect of different dose level and duration for two of most preservatives
commonly used in rats. The experiment was carried out on 70 adult male Sprague
Dawley rats weighing 150-200 gm. They have been divided into 5 groups each
group contain 14 male rat. The first group served as control group. Second group
maintained on ration contains sodium nitrite at concentration 0.2% of the diet.
Third group maintained on ration contains sodium nitrite at concentration 0.4% of
the diet. The forth group maintained on ration contains Butylated hydroxyltoluene
at concentration 0.4% of the diet. The fifth group maintained on ration contains
.Butylated hydroxyltoluene at concentration 0.6% of the diet. Samples were
collected twice from 7 rats/each group after 4 and 10 weeks. The biochemical
result of sodium nitrite treated rats show decrease in serum urea, creatinine and
heamoglobin. Increase activity of ALT, AST, ALP, total bilirubin with
predominance of the indirect bilirubin. Also, increase erythrocytic superoxide
dismutase. However, The biochemical result of BHT treated rats show decrease in
body weight accompanied by decrease in urea, creatinine level, ALP and hepatic
malondialdhyde. Moreover, increase activity of AL T, AST enzyme and increase
total bilirubin with predominance of the direct bilirubin, Erythrocytic Superoxide
dismutase and renal malondialdhyde.