الفهرس Only 14 pages are availabe for public view
 |  | from | 226 |  |  |
| | | from | 226 | | |
Abstract
Hyaline membrane disease (HMD), occurs almost exclusively in premature infants. The incidence and severity of RDS are related inversely to the gestational age of the infant. The outcome of RDS has improved in recent years with the increased use of antenatal steroids to improve pulmonary maturity, early postnatal surfactant therapy to replace surfactant deficiency, and gentle techniques of ventilation to minimize damage to the immature lungs. These therapies have also resulted in the survival of premature infants who are smaller and more ill. Over the last 50 years there have been dramatic improvements in the survival rate of neonates requiring intermittent positive pressure ventilation This has resulted from the introduction of ventilators specially designed for use in babies weighting as little as 500 gm and also from numerous studies attempting to optimize ventilatory techniques .This was a cohort study with different methods of mechanical ventilation applied in simple random order so that each patient served as his / her own control .
The aim of this study was to determine and compare the effect of SIMV and A/C on ventilation, blood gas exchange and mean ABP.
This study was carried out in the neonatal intensive care units . It included on one hundred neonates ,all are preterm and had diagnosed hyaline membrane disease . Patients were divided into two groups (G1&G2) in each group included fifty neonates .
An initial base line was recorded with the infants on conventional IMV and the ventilator settings were chosen by the clinical team , then the infants will be switched in simple random samples order to either A/C or SIMV .Vtmech is significantly higher during SIMV than during conventional IMV because positive airway pressure and negative intrathorasic pressure are in phase , resulting in a higher transpulmonary pressure .