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Abstract
The objective of this study was to identify prevalence of dyslipidemia
in type1 and type 2 Diabetes .And to assess the D-dimer level in both
Diabetic patients. Subjects and methods This study Comprised 90 children
and adolescents 26 male and 64female whom had been diagnosed as
having one of the types 1 or 2 of diabetes mellitus whom randomly chosen
from the regular attendants of the Pediatric Diabetic clinic, in Childern’s
Hospital, Ain Shams University. Patients were divided into two groups.
Group 1 included 50 children and adolescents with type 1 diabetes. They
were 12 males and 38 females. Their chronological age ranged between 5-
18 years with a mean of 13.9±3.9 years. Group 2 included 40 children and
adolescents with type2 diabetes. They were 14 males and 26 females.
Their chronological age ranged between4- 18 years with a mean of 13.5 ±
2.9 years. All patients were subjected to: History taking, clinical
examination with particular emphasis on anthropometric measures, body
mass index, assessment of maturity rating according to Tanner’s
classification, presence of other autoimmune disorders, local abdominal
examination especially for distention or tenderness, cardiovascular
reflexes for autonomic neuropathy, full neurological examination to detect
evidence of peripheral neuropathy, fundus examination using direct
ophthalmoscope for diabetic retinopathy, blood pressure were measured .
All patients had done the following laboratory investigations; Random
blood sugar (RBS), Glycosylated hemoglobin (HbAlC), Quantitative
determination of urinary micro albumin for diabetic nephropathy, Total
cholesterol, D-dimer levels in plasma. Results Type II diabetic patients
had a significant higher weight and weightSDS (p<0.01), and BMI and
BMI SDS (p<0.01) compared to type I diabetic patients. Type I diabetic
patients had a significantly longer disease duration compared to type II
diabetic patients (p<0.01). In type 1 diabetic patients their were a highly
significant relation between D-dimer and diabetic peripheral neuropathy
p<0.01) & diabetic retinopathy (p<0.01). In type II diabetic patients their
were a significant relation between D-dimer and peripheral neuropathy
p<0.05) and no significant difference with retinopathy (p>0.05). C-peptide
values were significantly higher among type II diabetics compared to type
diabetics (p<0.01). In type 2 diabetics their were a positive significant
correlation between cholesterol and BMI (r 0.48) & (p<0.05). In type 1
diabetic patients their were a highly significant correlation between Ddimer
levels versus systolic blood pressure (r 0.64 & p<0.01), diastolic
blood pressure (r 0.55 & p<0.01). In type 1 diabetics there were asignificant correlation between microalbuminuria and D-dimer and disease
duration. On the other hand there were a significant correlation between
microalbuminuria and D-dimer and Cholesterol in type 2 diabetics. the
ratio of diabetic patients with microalbuminuria in type 2 diabetics were
more than in type 1 diabetics with no statistically significant difference in
between. Conclusion There were no association between D-dimer and
cholesterol in both type1and type 2 diabetes mellitus. But elevated Ddimer
levels in both type 1 and type 2 diabetic patients and its association
with microvascular complications peripheral neuropathy, retinopathy and
nephropathy indicates hypercoagulability.