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Abstract
In the present work pathologic studies were done in order to evaluate the comparative effect due to administration of monensin (as one of the coccidiostatic ionophore antibiotics), tiamulin ( as a synthetic diterpene antibiotic) and oxytetracycline ( as one of the broadspectrum tetracycline group) either singly with their therapeutic levels or in a simultaneous administration (monensin with tiamulin or monensin with oxytetracycline). During these studies 72 male rabbits were used and grouped into 6 groups: three maintained as a positive control [GP,1 (monensin), GP,2 (tiamulin) and GP.3 (oxytetracycline)], other 2 treated groups [GP.4 (Monensin + Tiamulin) and GP.5 (Monensin + Oxytetracycline)] and the last group (GP.6) maintained as a negative control for the other groups. The used doses of monensin were 50 PPm of the 20 % formula in the diet. Tiamulin treatment (20 mg 7Kg B.W) given daily in drinking water for 5 successive days at the 1 week and then repeated at the 3 week. Oxytetracycline was given also daily (0.2 g/Kg. B.W) in drinking water for 5 successive days, then also repeated at the 3t week.
The pathologic studies were spotted on the myocardial and skeletal muscle, liver, kidneys, lungs and brain tissue. The results of these studies were indicative for some mild to moderate changes of toxicosis (vascular congestion and some mononuclear cell infiltrations in various organs, muscular degenerations, parenchymatous degeneration and few or small areas of necrosis in the liver and kidneys, peribronchial cellular reactions and emphysema in the lungs, neuronal degeneration, satellitosis and sometimes neuronophagia in brain tissue) sequentially in case of single monensin administration. The changes of monensin toxicosis were so severe and potentiated in case of simultaneous treatment of monensin with tiamulin where several areas of necrosis and mononuclear cell aggregations were seen in the myocardial as well as skeletal muscles, liver, kidneys and lungs in addition to some focal areas of malacia in brain tissue. No obvious or specific lesions of toxicosis could be detected in case of simultaneous administration with oxytetracycline.
It was concluded that the toxic-interaction between monensin and tiamulin led to occurrence of severe pathologic lesions similar to those related to the toxic lesions of monensi with high levels of administrations. In the same time, milder or no lesions for interaction with oxytetracycline could be occurred.