الفهرس Only 14 pages are availabe for public view
 |  | from | 81 |  |  |
| | | from | 81 | | |
Abstract
The present work comprised three studies on the use of the immunostimulant levamisole hydrochloride in sheep and goats vaccinated with attenuated PPRV-vaccine (Egypt-87). The aim was to find a way to maximize the obtained neutralizing antibody response to that vaccine. In the three trails, the same dose of both the PPRV-vaccine and levamisole were used to inoculate both susceptible sheep and goats subcutaneously. These doses were 3log10 TCID50 of PPRV-vaccine and 2mg/kg body weight of either sheep or goats. Results of the studies on both sheep and goats were approximate the procedure of the first trial was simultaneous inoculation of both the vaccine and levamisole. Such a procedure did not lead to exaltation of the neutralizing antibody response, since neutralizing antibody titres in treated animals were statistically indifferent from the positive control. Such a result might be attributable to dose unrepetition of levamisole. The second trial was proceeding with levamisole inoculation by 3 days before vaccination which was followed 3 days later with another dose of levamisole. In this trial, serum neutralizing antibody titres were statistically much higher than those of the first trial. It was perceivable to attribute such a result to an effective stimulation of the immune mechanism in treated sheep and goats. The third trial was carried out through inoculation of both the vaccine and levamisole thoroughly mixed together. In this case, obtained results were much lower than those of the first and second trials. This could be attributed to a probable deteriorating effect of levamisole on the antigenic peculiarities of the virus or it might be due to occurrence of some inoculation of the virus. It could be concluded that the procedure of repetition of dosing with levamisole hydrochloride could result in potentiation of the immune response to PPRV-vaccine in either sheep or goats.