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Abstract
Respiratory distress syndrome in preterm infants had been associated with inflammatory processes in the lung.
This study was designed to evaluate IL-12 at birth in preterm newborns with RDS as a marker of inflammation in pathogenesis and prognosis of RDS.
The study was included 55 neonates. The studied neonates were preterm newborns <35 weeks gestational age admmited to the NICU during the first 12hours of life. The study group included 30 preterm infants with RDS diagnosed clinically and by chest x-ray (patient group). They had mean gestational age 32.36 ± 1.53 weeks, birthweight 1.43 ± 0.33 Kg, 11males,19 females, 8were delivered vaginally and 22 were delivered by cesarean section. The control group included 25 preterm infants without RDS and apparently doing well with mean gestational age33.52 ± 0.65 weeks, birth weight 1.74 ± 0.21Kg, 9males, 16 females, 7 were delivered vaginal and 18 were delivered by cesarean section.
Those who had suspected or proved neonatal sepsis, perinatal asphyxia and congenital anomalies were excluded from the study.
All neonates were subjected to full history taking, thorough clinical examination, laboratory and imaging studies. IL-12 level at birth from cord blood was estimated as a marker of inflammation. All neonates were followed by clinical, laboratory investigations and imaging studies for detection of severity of RDS. IL-12 level after 48 hours of life was assayed
The study demonstrated that: patient group showed significantly decreased birth weight and gestational age than control group. There was no significant difference between the patients and controls as regards sex, mode of delivery, maternal pre-eclampsia, premature rupture of membrane, antepartum hemorrhage and maternal diabetes.
Mortality was significantly increased in patient group than control group.
Cord IL-12 differ insignificantly between both groups.
There was insignificant difference in the level of interleukin 12 at birth between patients with different grades of RDS according to silverman score and chest x-ray grading.
Level of cord IL-12 was highly significantly increased in non surviving than surviving patients.
Level of IL-12 was highly significantly decreased after 48 hours when compared to its level at birth in patient group.
IL-12 level at birth was positively correlated with hematological score of sepsis.
No correlation was detected between cord IL-12 and IL-12 after 48 hours. No correlation was found between IL-12 at birth or after 48 hours and different studied parameters.