الفهرس 
Classification of Hypertensive disorders with pregnancyOnly 14 pages are availabe for public view
 |  | from | 143 |  |  |
| | | from | 143 | | |
Abstract
Preeclampsia is a potentially serious condition that still accounts for significant morbidity and mortality for the mother and the neonate; complicating 5 - 7% of all pregnancies and exposing them to a 3 to 25 fold increased risk of severe obstetric complications. It is now widely accepted that vascular endothelial dysfunction is the most astonishing and the principal event in the pathophysiology of the disease Researchers investigated the fact that ischemic placenta secretes soluble substances in the maternal circulation. Among these is soluble endoglin (sEng), a shed part of endoglin receptor. sEng is a potent anti-angiogenic molecule that acts by antagonizing the effects of TGF-β1 in vasculature via capturing and diverting them away from endoglin receptor. Deprived from the angiogenic and NO-dependant vasodilator TGFβ1 molecules, the blood vessels are subjected to intense vasospasm and death of the lining endothelial cells with resultant leakage of proteins in tissues and urine The aim of this thesis was to study serum soluble sEng in patients with preeclampsia and gestational hypertension to assess its diagnostic importance in preeclampsia. This study was conducted on This study was carried out on 74 women. Fifty three of them were patients who were attendants and inpatients of Obstetrics and Gynecology Department of Minoufiya University Hospital and twenty one healthy pregnant controls. Patients and controls were age matched. Controls (group1) were classified as preterm controls (group1a, included 11 women)and full term controls (group1b, included 10 women). Patients included in this study were classified as gestational hypertension group (group 2, included 23 women). It was divided into gestational hypertension preterm (group 2a, included 11 women) and gestational hypertension full term (group 2b, included 12 women). In addition, 30 preeclamptic patients were also included (group 3) who were classified as preterm preeclampsia (group 3a, included 16 women) and full term preeclampsia (group 3b, included 14 women).