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Abstract
The management of post-operative pain has become one of the principle missions of the anesthesiologist and the effective treatment of post surgical pain still poses unique challenges for practitioners. (1)
The aim of this study was to study the effectiveness of perioperative gabapentin administration on the postoperative pain and opioid consumption following single lumber disc surgery.
The study was carried out on 60 adult patients 19-65 years old, ASA I-II undergoing elective single lumber disc surgery under general anesthesia in Neurosurgical Department of Alexandria Main University Hospital.
The patients were randomly categorized into two equal groups according to the closed envelope technique:
• Group A: 30 patients received four capsules of 300 mg gabapentin preoperative orally; three capsules in the day before surgery (one capsule every 8 hours), and one capsule two hours before induction, then they were continue postoperative by another three capsules (one capsule every 8 hours), started 3 hours postoperative.
• Group B: 30 patients received four placebo capsules preoperative orally; three capsules in the day before the surgery (every8 hours), and one capsule two hours before induction, then were continued postoperative by another three capsules.
Patients received interavenous fentanyl (1µg per kg) three minutes before induction of anesthesia.
All patients received a sleeping dose of thiopentone sodium (4-5mg per kg) intravenously and tracheal intubation was facilitated with rocuronium (0.6 mg per kg). Then patients connected to closed circuit machine and anesthesia maintained with isoflurane 1% in oxygen and air (1:1) and respiration was mechanically controlled to maintain end-tidal CO2 concentration between 36 and 38 mmHg.
The following measurements were carried out:
8- Heart rate (beat per min).
9- Mean arterial blood pressure (mmHg).
10- Respiratory rate (cycle per minute).
11- Oxygen saturation (SpO2%).
These previous parameters were measured and displayed continuously by using multichannel monitor. The mean values for heart rate and blood pressure were recoded at the following times:
• Baseline 5 minutes before induction of general anesthesia.
• After complete recovery of the patient and then every 4 hours during the first 24 hours postoperative.
12- postoperative pain was assessed by direct questioning on visual analogue scale and was recorded as follow:
• One hour after the end of surgery (after complete recovery of the patient