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Abstract 1- Eimeria stiodae is the most serious spocies of Eimeria, found in the rabbita tnd causes hepatic coccidiosis. Diagnosis of this disease was done by oocysts detection, count, sporulation and excy¬station of sporulated oocysts to abtall~ the sporo- zoitese 2- ”In vitro ” expemments. Ca) Chick embryos inoculation by E. stiedae sporo¬zoites, ~hich showed a negative result. Cb) Examination of the effoct of the suggested drugs against intact sporozoites, which had no no noticaable effect. 3- UIn vivo” experiments. Ca) Stuqp.ng the effect of (sulphaquinoxaline, darvisul, whityns-s, amprol, terrJillYci...’1. and colifuran), :in naturally infected rabbits by E~ stiedae~ By using different dose levels against 210 infected ri’tbbits for a period of 16-20 days. Three effective drugs against hepatic coccidiosis were selected. The minimum effective dose was 20 mg. /Kg. bod~ weight from sulphaquinoxaline, 0.25 ml./kg. body weight from darvisul and 0.07 ml,/kg. body vleight of whit yns-s. Cb) For stud~ the site of action of the effec¬tive drugs 330 experimentally infected rabbits by ~. stiedae were used. The drugs were given for a period of 21 days, in their effective dose. Both darvisul and whityns-s were seen to be able to destroy all the stages of ~. stiedae, but sulphaquinoxaline inhibited the asexual stage only. 4- from this work we have suggosted that the drugs of choice for the treatment of hepatic coccidiosis in rabbits ace: (a) Dnrvisul on 0.25 ml./Kg. bod~ woight daily for 8 days. (b) Whityns-s on 0.07 ml./Kg. bo~ weight daily for 9 days. |