الفهرس 
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Abstract
Food adjuvants as vitamins in megadoses or growth promoter such as anabolic agents may be of value in combatting drug toxicities. In the present study the interaction between vitamin A (vit. A), the anabolic steroid methenolone acetate (M.A.), and the global
schistosomicidal drug praziquantel (PZQ) was studied hopefully to reduce the side effects of the latter.
For this purpose, the acute and subchronic toxicities
of PZQ in rats were studied. The experiments were repeated
using PZQ given along with vitamin A, along with methenolone acetate, or along with a combination of both
vito A, and M.A. (A) Acute toxicity studies: The results of the ~study revealed the following
findings: 1 Praziquantel with combination of vitamin A and the
anabolic compound methenolone acetate (M.A.) markedly
reduced the acute toxicity of praziquantel at the LD16
level. 2 At the highly fatal dose levels of PZQ i.e. LDso, and
LOa4, the adjuvants failed to protect against PZQ
toxicity.(B) Short ter.m chronic toxicity studies:
These studies were done on 80 adult male albino rats
divided into 8 equal groups each comprising 10 rats.
The groups received either PZQ (450 mg/Kg twice
weekly), alone, or in combination with vito A (10,000 IU/Kg
daily), or with M.A. {l.8 mg/Kg daily}. The treatments were
continued for 8 weeks. Parallel groups receiving the adjuvants alone were also run. Biochemical analysis of the
serum were carried out after 4 and 8 weeks of treatment and
included; total protein, albumin, globulin, transaminases
(GPT and GOT), alkaline phosphatase, bilirubin, glucose, creatinine and urea.
Body weighing, internal organs weighing as well as blood hematological examinations were carried out at end of
experimentation period.
The results of this study revealed the following: 1 Praziquantel markedly reduced body weight gain. This
effect was abolished by vito A, and to a lesser degree
by the anabolic (M.A.) and its combination with vito.