الفهرس 
INTRODUCTION
Corynebacterium Pseudotuberculosis (C.ovis) infection in sheep and goatsOnly 14 pages are availabe for public view
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Abstract
SUMMARY
By experimnta1 infection of C. ovis in buff aloe calves with the strain (A Bu 77), we can reach to a conclusion that, using the intradrma]. route of injection tht organism remc.ins mostly in the local skin lesion and cn spread only to the regional lymph nodes, this ws proved by immunoflourescence studies, more over, the organism was found mostly intrace— liularly probably in macrophages and has affinity to lymphatics and their endothelial linings, this was proved also by immi.mofluorescence studies and also by histomorphological features.It was found that the reacting cells to infection are polymorphnucleur leucocytes and histiocytes and the latter cells re the most predominent reacting cells after the few first days of infection.The strain of C. ovis under investigation has got acytotoxic effect manifisted by erly extensive cellular destruction and nuclear fragmentation which characterizes the lesion in skin and regional lymph nodes.Besides these cytotoxic effect, it was proved that the exotoxin of the organism hs got a hepatotoxic as well as nephrotoxio properties and this was mnifisted by the advanced dystrophic chngs found in the liver which could be detected by the liver function tests nd tubulonephrosis with early glomerular ch.ngs observed in the kidney. In Adition, this exotoxin hu got a hemolytic effect mnifistdd by the increase in haemosidrin in spleen and DROP in rythrocytic count, P.C.V., and Hb level.
We can also summarize the general pLthologicJ picture of experimental infection with the strain under invstigution as being characterized by lymphangitis, vascu1r damage, thrombosis, oedem, cellulcar inuiltratio und necrosis.