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Abstract
When body temperature rises above its normally regulated range, because of environmental factors or excess metabolic heat production, irreversible thermoregulatory failure may be rapidly developed if body response were not happened. Repeated heat stress trigger a complex program of gene expression and biochemical adaptive responses as these responses were important for ability of animals to cope with that stress.
Fifty male Sprague-dawley rats (100+ 10gm, 1month old) were used in this study. The animals were obtained from the central animals house of faculty of Veterinary Medicine, Zagazig University .Animals were maintained in stainless steel cages in the biochemistry department under hygienic condition. The animals received standard rat pellet diet and water ad libtum. The animals were segregated into five groups, 10 animals each. These are as follow:
First group (control group): rats were decapitated at end of February.
Second group : rats were decapitated at end of April.
Third group : rats were decapitated at end of June.
Fourth group : rats were decapitated at end of July.
Fifth group : rats were decapitated at end of August.