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Abstract
Non-Hodgkin Lymphoma (NHL) is a cancer of the cells of the lymphatic system. NHL can start almost anywhere in the body. It may occur in a single lymph node, a group of lymph nodes or an organ such as the spleen . It can spread to almost any part of the body, including the liver, bone marrow and spleen Diffuse large B-cell lymphoma (DLBCL) is the most common type of NHL and comprises 30% of newly diagnosed cases. Most patients present with rapidly enlarging masses, often with symptoms both locally and systemically designated B symptoms with fever, recurrent night sweats or weight loss Mantle cell lymphoma (MCL) is a distinctive disease entity characterized by specific histopathologic, immunologic and cytogenetic features and has an aggressive clinical course. MCL comprises approximately 2-10% of all NHL Immunophenotypic analysis of NHL is essential for the differentiation of various NHL subtypes, proper diagnosis and choice of treatment for each subtype. It can be performed by flow cytometry and/or immunohistochemistry Flow cytometry (FCM) is a technology that allows a single cell to be measured for a variety of characteristics, determined by looking at how they flow in liquid. Instruments used for this can gather information about cells by measuring visible and fluorescent light emissions, allowing cell sorting based on physical, biochemical and antigenic traits The aim of this work is to study the peripheral blood and bone marrow immunophenotypic features of lymphomatous cells among patients with NHL attending Menoufyia University Hospitals. This work aims also to study the.
cytometry in the diagnosis of NHL.