الفهرس 
Introduction and Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
in the present work , an attempt has been made to study the effect selenium administration on the development of gastric ulcer in male albino rats subjected cold-restraint or conc. Ethanol intake. Selenium is the cofactor of GSHPx which is considered one of the antioxidant enzymes that play a major role in scavenging reactive oxygen species particulary H2O2 which has an important role in the pathogenesis of gastric mucosal injury. In concludion , this study demonstrated that selenium chloride at a protective effect against both ethanol and cold-restraint stress induced gastric ulcer. This could be attributed to ehancing GSHPx activity and detoxifying oxygen free radical formed under such condition. Although further research is required in the future, yet the data open the way for utilization on selenium as an additional atiulcer drug in addition to the classic antisecretory ones.