الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
Aim of the work
1- Evaluation of the state of coagulation system activity as indicated by rate of thrombin generation in children with nephritic syndrome.
2- Determination of TFPI plasma level changes in childhood nephritic syndrome.
3- Study the probability of correlations between rate of thrombin generation; TFPI plasma level and plasma lipoprotein levels.
Conclusion
1- Nephrotic patients have a higher rate of thrombin generation than control as determined by the increased level of F1+2. There is shortened PT and APTT. The high level of F1+2 is not correlated with serum total cholesterol, HDL- cholesterol, LDL- cholesterol, triglycerides, serum albumin or quantitative urinary protein.
2- TFPI level is increased and is positively correlated with serum total cholesterol, LDL-cholesterol, triglycerides in nephritic children. The increased TFPI plasma level may be a defensive mechanism against the increased coagulation system activity.
3- Thrombocytosis may be a contributing factor in the hypercoagulable state present in nephritic children.
4- Nephrotic children have a higher level of serum total cholesterol, LDL-cholesterol and triglycerides and low level of HDL-cholesterol; that may also add another risk in increasing the incidence of thromboembolic complications.