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Abstract
The Present Study Was Conducted To Investigate The Rate Of GSTTI Null Genotypes In AML Patients As A Risk Factor And Its Importance In Prognosis Of The Disease. The Glutathione S-Transferase (GST) Family Of Metabolizing Enzymes That Plays An Important Role In The Metabolism And Detoxification Of Mutagens, Carcinogebss And Anti-Cancer Drugs. In Hematological Malignancies, An Association Has Been Shown Between GST- Null Genotype And An Increased Risk Of Developing Acute Leukemia. Also Glutathione S-Transferases (GSTs) Have Been Associated With Outcome In Human Cancers Treated With Eytotoxic Chemotherapy.