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Abstract various new sulphonamides. sulphonanilides, sulphonehydrazides, sulphonylhydrazdes, saccharinderivatives and other related compounds were prepared. Thus, condention of the sulphonyl chloride with different amines gave the sulphonamides of type . Reduction of the nitrosulphonamides gave the corresponding amino derivatives , which readily reacted with aldehydes to give the arylidenesulphonamides . Oxidation of the sulphonyl chloride gave the corresponding acid which reacted also with amines to give the sulphonamides. Cyclisation of the sulphonamides with hot hydrochloric acid gave the corresponding saccharin dervatives. The acid chloride was also prepared then it was condensed with amines and with o-nitrophenol to give the corresponding sulphamido carboxamides and sulphamido-ester respectively. Similar sulphamido carboxamides and sulphamido esters of type were also prepared. The sulphamido chalcones were also prepared and reacted with hydrazines and with urea to give the pyrazole derivatives or the pyrimidine derivatives. A series of hydrazides of type were also prepared. The unsubstituted hydrazide was condensed with acetylacetone or benzoylacetone and the formed hydrazones were cyclized to the corresponding phrazoles. The hydrazide was also obtained and treated with acetylacetone to give the hydrazide hydrazine. Cyclisation of gave the corresponding pyrazole derivatives. All the above compounds were screened against different species of bacteria and some of them were found to be active. The structure of the prepared compounds sas discussed in the light of elemental analysis, I.R and N.M.R. spectra. |