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Abstract
The aim of the present investigation was to study the effects of vitamin E administration on cardiovascular performance and DNA changes in hypertensive rats.
48 white male albino rats were used in this investigation. Rats were classified into the following groups:
(I) Normotensive Group:
(Ia) Normotensive non-treated group.
(Ib) Normotensive antioxidant treated group.
(II) Hypertensive Group:
(IIa) Hypertensive non-treated group.
(IIb) Hypertensive vitamin E-treated group.
(IIc) Hypertensive ACE-I treated group.
(IId) Hypertensive vitamin E and ACE-I treated group.
In all of the previously mentioned groups the following investigations were done:
i. Measurement of arterial blood pressure.
ii. Assessment of cardiac performances (contractility and rhythmicity).
iii. Measurement of blood flow.
iv. Detection of DNA changes.
v. Laboratory investigations:
1. Lipid profile.
2. Serum sodium and potassium levels.
3. serum total antioxidative capacity.
The results showed that, oral vitamin E administration (60 mg/kg B.W.) for 4 weeks, to normotensive rats resulted in insignificant changes in the mean systolic blood pressure, cardiac contractility & rhythmicity, renal blood flow & renal vascular resistance, DNA & RNA, total antioxidative capacity, fasting serum sodium & potassium and lipids when compared to the corresponding values in normotensive non-treated group.
In hypertensive non-treated group, by administration of DOCA-salt (50 mg/kg)) for 4 weeks, there was a significant increase in mean systolic blood pressure, renal vascular resistance, heart rate, RNA, fasting serum sodium, cholesterol, triglycerides and LDL, and total cholesterol/ HDL ratio, and a significant decrease in cardiac contractility, DNA, renal blood flow velocity, serum total antioxidative capacity, fasting serum K+ and HDL levels when compared to the corresponding values in normotensive non-treated group.
In hypertensive vitamin E-treated group, by vitamin E administration (60 mg/kg B.W.) for 4 weeks, there was a significant decrease of MSBP, heart rate, renal vascular resistance, fasting serum Na+, total cholesterol, triglycerides, LDL levels and total cholesterol/ HDL ratio and a significant increase in cardiac contractility, renal blood flow, total antioxidative capacity, fasting serum K+ and HDL levels when compared to the corresponding values in hypertensive non-treated group.