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Abstract Human semen is ejaculated as a gray yellowish fluid that forms a semisolid, gel-like coagulum immediately after ejaculation. The clot usually liquefies spontaneously and completed within 5 to 20 minutes leaving the ejaculate a liquid. The dissolution of the seminal clot occurs both in vivo and in vitro. The transient coagulative state allows the sperm to interact with other factors in the seminal plasma, and exchanges various important biomolecules Lwaleed et al., 2007b). Sg I and Sg II are proteins of human seminal plasma that together with fibronectin give rise to the gel-like coagulum of newly ejaculated semen and they are considered the main component of human semen coagulum. They originate chiefly from seminal vesicles (Jonsson et al., 2005 Non-coagulated semen may occur with congenital bilateral absent vas (CBAV or bilateral ejaculatory duct obstruction because semen in these conditions is devoid of the seminal vesicles secretions (Lwaleed et al., 2004). Liquefaction of human semen is a process in which the semen is converted from semisolid form to liquid form. It occurs within 5 to 20 minutes of ejaculation in vivo and is prolonged by up to 30 minutes in vitro at room temperature. It is an important step facilitating sperm motility, thereby enabling progression up the female reproductive tract (van Dreden et al., 2007). Human seminal plasma contains proteolytic enzymes which are implicated in the degradation of seminal proteins to protease and free amino acids. They are responsible for initiating and promoting seminal coagulum dissolution. They arise chiefly from prostate (Lwaleed et al., 2007a). Semen contains enzymes and inhibitors of the haemostatic system which are involved in regulation of the |