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Abstract
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the common malignant neoplasms of the skin. BCC is characterized by local invasion and contiguous spread. SCC is a biologically aggressive tumor and usually metastasize. Following local invasion and tissue destruction, SCC commonly metastasizes to lymph nodes.
P63 is a recently identified gene that it is mapped to chromosome 3q27.This gene encodes six different isoforms which have either transcavating or dominant negative effects on P53-reporter genes.
P63 protein is consistently expressed in the basal cells of stratified epithelia, and glandular structures. In skin, p63 is considered as a reliable keratinocyte stem cell marker, and is used in the identification of these cells in the normal skin and the tumors of epidermis and epidermal appendages.
The aim of the work is to study the expression of p63 in cutaneous basal cell carcinoma and squamous cell carcinoma and correlate this expression with the clinico-pathological parameters.
This study was done on 35 cases composed of 25 basal cell carcinoma cases, 10 squamous cell carcinoma cases and seven control subjects.
The ages of BCC patients ranged from 6 to 85 years with mean ± SD 52.8 ± 23.3. Sixteen (64%) of them were males and 9 (36%) cases were females with a male to female ratio of 1.8:1.
The ages of SCC patients ranged from 5 to 80 years with mean ± SD 53.8 ± 23.8. Eight (80 %) of them were males and 2(20%) cases were females with a male to female ratio of 4:1.