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Abstract
Acute coronary syndromes (ACS) are a diagnostic and pathophysiologic continuum ranging from unstable angina (UA) to Q wave
myocardial infarction (MI). The myocardial ischemia of UA and MI results
from excess demand or inadequate supply of oxygen. The acute reduction
in coronary arterial perfusion resulting in ACS is primarily due to an
atherosclerotic plaque disruption with superimposed thrombosis.
A growing body of evidence supports the concept that local and
systemic inflammatory response plays a role in the initiation and
progression of atherosclerosis and its complications (Sivaraman et al,
2004).C-reactive protein (CRP) is an acute phase reactant marker for
underlying systemic inflammation. It is not known whether CRP is a
marker of atherosclerotic burden (a disease marker) or whether it reflects
a process e.g. inflammatory fibrous cap degradation (a process marker)
leading to acute coronary events (Auer et al, 2002) .
The aim of this study was to evaluate the serum hsCRP levels in
patients with ACS and to compare its serum levels between patients with
UA & patients with AMI.
This study included 50 subjects, 38 of them were patients suffering
from ACS either UA or AMI which they were referred as group A and
group B respectively. The other 12 subjects were apparently healthy control
and they were referred as group C.
A fasting morning sample of venous blood was withdrawn from each
patient as well as from healthy volunteers. For each subject, FBS, TC, TG,
HDL-c and total CK were measured on open system autoanalyzer,