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Abstract Acute coronary syndromes (ACS) are a diagnostic and pathophysiologic continuum ranging from unstable angina (UA) to Q wave myocardial infarction (MI). The myocardial ischemia of UA and MI results from excess demand or inadequate supply of oxygen. The acute reduction in coronary arterial perfusion resulting in ACS is primarily due to an atherosclerotic plaque disruption with superimposed thrombosis. A growing body of evidence supports the concept that local and systemic inflammatory response plays a role in the initiation and progression of atherosclerosis and its complications (Sivaraman et al, 2004).C-reactive protein (CRP) is an acute phase reactant marker for underlying systemic inflammation. It is not known whether CRP is a marker of atherosclerotic burden (a disease marker) or whether it reflects a process e.g. inflammatory fibrous cap degradation (a process marker) leading to acute coronary events (Auer et al, 2002) . The aim of this study was to evaluate the serum hsCRP levels in patients with ACS and to compare its serum levels between patients with UA & patients with AMI. This study included 50 subjects, 38 of them were patients suffering from ACS either UA or AMI which they were referred as group A and group B respectively. The other 12 subjects were apparently healthy control and they were referred as group C. A fasting morning sample of venous blood was withdrawn from each patient as well as from healthy volunteers. For each subject, FBS, TC, TG, HDL-c and total CK were measured on open system autoanalyzer, |