الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
This work was done to study the effect of terbinafine as a new
antifungal drug on the livers of adult albino rats.
Forty eight adult male albino rats weighing 180-200 gms were used.
They were divided into five groups, as follows :
Group I:
8 rats were used as controls for each experimental bJfOUP and
received only distilled water by oral tube.
, ,
Group II :
10 rats, each received 5mg/kg body weight of terbinafine daily by
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oral tube for two weeks.
Group III:
10 rats, each rat received Smg/kgbody weight ofterbinafine daily
by oral tube for six weeks.
Group IV:
10 rats, each rat received Smg/kg body weight terbinafine daily by
oral tube for twelve weeks.
The lipid DROPlets were increased gradualy with increasing period of
terbinafine administration.
The Iysosomes were proliferated in all treated groups. The
peroxisomes were proliferated in groups III and IV.
The nuclei showed fragmentation of their nucleali especially III
groups III and IV.
Areas of hyDROPic degeneration were seen in some hepatocytes in
all treated groups. ,,
Signs of cholestasis were obvious only in group IV in the form of
dilated bile canaliculi and pericanalicular biliary deposits. Some of the
blood sinusoids showed infiltration with lymphocytes, polymorplullIclear
leucocytes and plasma cells in groups III and IV. Also some of them were
surrounded by collagen fibrils in group IV. Hypertrophy of endothelial and
kupffer cells were seen in all treated groups.
All prevIOus light and electron microscopic changes disappeared
and livers returned to the normal picture after one month from drug
withdrawal.
from the present study, it could be concluded that the toxic effects
therapeutic doses of terbinafine for prolonged periods had toxic effects on
the livers or rats and were reversible after drug withdrawal.