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Abstract
Diabetic nephropathy is a clinical syndrome characterized by a set of structural and functional kidney abnormalities in patients with diabetes mellitus and is the leading cause of end stage renal failure Endothelial dysfunction is a common feature in diabetic patients and is associated with inflammation and increased levels of circulating soluble adhesion molecules including serum vascular cell adhesion molecule (sVCAM-١). VCAM-١ is a human gene and a member of the Ig Super family. It encodes a cell surface sialoglycoprotein expressed mainly by cytokine activated endothelium. This type immune membrane protein mediates leucocytes- endothelial cell adhesion and signal transduction and is thought to play an important role in inflammatory and immune responses This work aimed to evaluate VCAM-١ as marker of microrvascular dysfunction in patients with diabetic nephropathy The present study included thirty six (٣٦) diabetic patients (٢١ males and ١٥ females) with mean age ٤٩-٨٩± ١١٫٥ (range ١٨-٦٨ years The control group comprised of ١٤ apparently healthy individuals (٧males and ٧ females) with mean age ٤٤٫٢١ ± ٧٫٣٧ (range ٣٢-٥٧ years) matched gender, and age with diabetic patients Diabetic patients were divided into ٣ groups according to urinary albumin excretion Group١: Fifteen (١٥) diabetic patients without normoalbuminuria Group ٢: eleven (١١) diabetic patients with microalbuminuria.Group٣: Ten (١٠) diabetic patients with macroalbuminuria.In addition to control group who were fourteen healthy subjects chosen to be age gender matched with the previous groups.