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Abstract
Sickle cell disease )SCD( is one of the most common genetic diseases with some 250,000 new births each year.
Most patients suffer intermittent pain crises and life-threatening events while life expectancy is considerably reduced.
The aim of this study was to outline the factors that predict a severe course of sickle cell disease e.g. hemoglobin concentration, HbF concentration, and leukocytic count. We also aimed to study the clinical and laboratory effects of hydroxyurea on SCD as well as the role of the.adhesion molecule CD47 in the disease:The study was conducted on two groups The first group consisted of 48 patients. Their mean age was 9±4.27 yrs.
The median age for this group was 8.5 yrs.
The second group consisted of 20 normal subjects, as a control group, their mean age was 9.67 ± 4.53 yrs. The median age for this group was 9 yrs The first group further divided into two subgroups, group A, patients who are not on HU therapy, and group B, patients on HU therapy. The patients were also subdivided into three groups, patients in steady state not on HU therapy )G1(, patients in steady state on HU therapy )G2(, and patients presented with painful crisis )G3(.