الفهرس 
Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
The present study was carried out to evaluate the effect of ionizing radiation on the brain which is one of the sensitive organs that is affected by numerous factors including ionizing radiation. The brain may be especially prone to radical damage because, first, the membrane lipids are very rich in polyunsaturated fatty acids (PUFA)side chains ; second the brain is poor in catalase activity and has only moderate amounts of superoxide dismutase (SOD) and glutathione peroxidase. So the present study was aimed to determine the influence of intraperitoneal injection of either anserine, which is a known antioxidant, or\and zinc , an antioxidant metal, on brain content of radioprotective biogenic amines such as serotonin, dopamine, norepinephrine, histamine and on brain content of the inhibitory neurotransmitter gamma amino butyric acid the study was also extended to measure the direct antioxidant effect of anserine and zinc by measuring the extent of lipid peroxidation and protein oxidation. from all the results obtained in the present study, we can conclude that anserine, a naturally histidine dipeptide, has a curative effect against gamma radiation-induced brain damage. Also zinc has prived to have a slight potentiating effect along with anserine. So it is better to recommend a collective combination of anserine and zinc in treatment of radiation induced brain damage.