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العنوان
Synthesis and Biological Investigation of some New Nitrone and Pyrazole-3-Carboxylic Acid Derivatives /
الناشر
Mohamed Ramadan Eisa,
المؤلف
Eisa, Mohamed Ramadan.
هيئة الاعداد
باحث / Mohamed Ramadan Eisa
مشرف / Abdel-Hamed Nagib Ahmed Kafafy
مشرف / Hisham A.Abdel-Nabi
مشرف / Mohamed Fouad Radwan
الموضوع
Medicinal Chemistry Nitrone Carboxylic Acid
تاريخ النشر
2005 .
عدد الصفحات
167 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
العلوم الصيدلية
تاريخ الإجازة
1/1/2005
مكان الإجازة
جامعة المنيا - كلية الصيدلة - الكيمياء الطبية
الفهرس
Only 14 pages are availabe for public view

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Abstract

Scope of investigation: it deals with the rational upon which the synthesized compounds have been designed and it contains a general scheme which summarizes the sequence of reactions followed for synthesis of the desired compounds. It states the main objectives of design and synthesis of pyrazole-3- carboxylic acid derivatives and contains a general scheme which illustrates the sequence of reactions followed for synthesis of the target compounds. It describes preparation of the key intermediates 2-chloroquinoline-3-carboxaldehyde derivatives 80a-g, N-phenyl hydroxylamine 81 and preparation of the target compounds C-(chloroquinoline)-N-phenyl nitrone derivatives 82a-g. Elmental analysis and spectral data ascertained the structures of the synthesized compounds, in addition, it describes the formation of 4,5-dibenzoyl-3-(2-chloroquinoline-3-yl)-2-phenyl isoxazolidine 84 through the cycloaddition reaction of 82a and dibenzoyl ethylene 83. The results showed that compounds 82a-g pretreatment offered a potential protection against the action of ethanol including ulcer formation and lipid peroxidation. In addition , compounds 82a-g significantly decreased the concentration of malondialdehyde (an indicator of lipid peroxidation).