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Abstract Scope of investigation: it deals with the rational upon which the synthesized compounds have been designed and it contains a general scheme which summarizes the sequence of reactions followed for synthesis of the desired compounds. It states the main objectives of design and synthesis of pyrazole-3- carboxylic acid derivatives and contains a general scheme which illustrates the sequence of reactions followed for synthesis of the target compounds. It describes preparation of the key intermediates 2-chloroquinoline-3-carboxaldehyde derivatives 80a-g, N-phenyl hydroxylamine 81 and preparation of the target compounds C-(chloroquinoline)-N-phenyl nitrone derivatives 82a-g. Elmental analysis and spectral data ascertained the structures of the synthesized compounds, in addition, it describes the formation of 4,5-dibenzoyl-3-(2-chloroquinoline-3-yl)-2-phenyl isoxazolidine 84 through the cycloaddition reaction of 82a and dibenzoyl ethylene 83. The results showed that compounds 82a-g pretreatment offered a potential protection against the action of ethanol including ulcer formation and lipid peroxidation. In addition , compounds 82a-g significantly decreased the concentration of malondialdehyde (an indicator of lipid peroxidation). |