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Abstract
Candida colonization in immunocompromised patients represents high risk factors in development of candidaemia especially in neonates.
Duration of hospitalization had also a role in development of candidaemia due to prolonged exposure to broad- spectrum antibiotics and invasive procedures like catheterization.
Although C. albicans remains the most common cause of human candidiasis, other Candida species such as C. glabrata, C. tropicalis, C. krusei and C. parapsilosis are emerging as opportunistic pathogens that are more resistant to antifungal agents.
This study was designed to determine the prevalence of different Candida species as a cause of infections in immunocompromised patients, assess the relation between Candida colonization and candidaemia.
Also estimate the rate of candida carriage among hospital staff and test the susceptibility of candida isolates to antifungal agents including the new triazole voriconazole.
Also to determine whether or not there is DNA damage in immunocompromised patients using the DNA fragmentation assay.
Also to assess the usefulness of PCR in early detection of candidaemia in immunocompromised patients and assure the rapidity of PCR compared to culture methods of detection.
To achieve these objectives three groups, were included in this study.